Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Zhenyan Brand SheDiary Luxury Face Lifter Cream High End Private Label Japanese Skincare with Arbutin Camellia OEM Face Creams When Good Drugs Go Bad: Acetaminophen Toxicity tl;dr pharmacy g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram