Two chromatographic methods for analyzing paracetamol in spiked human plasma with its toxic metabolite, N acetyl parabenzoquinone imine and its antidote, N acetyl l cysteine Scientific Reports GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis?: Trends in Molecular Medicine Frontiers Liquid Chromatography Tandem Mass Spectrometry Analysis of Acetaminophen Covalent Binding to Glutathione S Transferases