The metabolic pathways of acetaminophen (APAP) in the human body. The Download Scientific Diagram How a common drug causes liver failure EurekAlert! GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins.
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napqi and glutathione The metabolic pathways of acetaminophen (APAP) in the human body. The