The Hidden Impact of Acetaminophen Well Rooted Figure 1 from Acetaminophen toxicity and 5 oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP depleting futile cycle and the other a useful cycle. Semantic Scholar Acetaminophen, Acetylcysteine, and Anaphylaxis With a Twist BROWN EMERGENCY MEDICINE BLOG Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.