Frontiers Growth Hormone and Insulin Like Growth Factor Action in Reproductive Tissues How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin GH and IGF 1 Regulation of Three Metabolic Pathways. GH inhibits Download Scientific Diagram GHK Cu Peptide Progress: Week 3 Results