Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which You can't out skincare internal depletion. Glutathione is one of the most important (and often overlooked) players in both skin clarity and overall wellness. When your body is overloaded, it shows up as: Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram