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coadministered cagrilintide and semaglutide in adults with overweight or obesity New in the August 14, 2025, issue of NEJM: Cagrilintide–Semaglutide for Overweight or Obesity (REDEFINE 1 phase 3a trial) Cagrilintide– Semaglutide for Overweight and Diabetes (REDEFINE 2 phase 3a trial)