Estrogen Metabolism, Detoxification, and Methylation Dr. Daniel Metzger, DACM, L.Ac. Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice Communications Biology MTHFR and glutathione's role in detoxification and methylation Methylation is happening nearly one billion times per second in your body. It influences detoxification, inflammation, neurotransmitters, hormone balance, cardiovascular health, brain function, and even how your DNA expresses itself. Yet most