Citalopram Induced Oral Melanotic Macules in a Female Patient and a Review of the Literature Cureus Does anyone know what this black mark on my lip is? Started last August so it's I've had it nearly a year, was living in Spain at the time for 6 months Melanotic Macules, Naevi, and Melanoma Springer Nature Link Tiny brown spot on the lip? Don't ignore it. A melanotic macule is a small, well circumscribed brown to black oral lesion most commonly seen on the lower lip and a high yield ADC exam favourite.